• br Conflict of Interest Both GM and

  2021-12-22

  

  Conflict of Interest Both GM and BDH are shareholders in Caldan Therapeutics, a company exploring potential novel treatments for type 2 diabetes. Acknowledgments Work described herein was supported by Biotechnology and Biological Sciences Research Council [grant BB/K019864/1)] (to GM) and [gr

• The global spread and ever increasing incidence of

  2021-12-22

  

  The global spread and ever-increasing incidence of metabolic syndrome over the past few decades has not only categorized it as an ‘epidemic’ but has also dramatically increased the risk of cardiovascular diseases and diabetes. The increase in prevalence of diabetes in the United States alone has bee

• To overcome these limitations investigators have

  2021-12-22

  

  To overcome these limitations, investigators have developed novel strategies for identifying and purifying gonadotropes from transgenic mouse models. For example, FSH-producing gonadotropes have been tagged in vivo with a transgenic cell surface antigen (H-2Kk) so that they can be purified in vitro

• It is important to underline that

  2021-12-22

  

  It is important to underline that a66 although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food intake and reward

• There are additional implications of subunit

  2021-12-22

  

  There are additional implications of α2-subunit alterations in the hippocampus. P has anticonvulsant activity (Herzog, 1995, Herzog et al., 1997, Herzog et al., 2012, Reddy et al., 2001, Reddy, 2010). These actions result from the metabolic conversion of P to GABA-A receptor-modulating, antiseizure

• br Declarations of interest br

  2021-12-21

  

  Declarations of interest Founding information This work was partially supported by the New Energy and Industrial Technology Development Organization (NEDO) Japan [grant number P03043]; and Grants-in-Aid for Scientific Research [grant number 16H00738 to H.M.] from the Japan Society for the Prom

• lumiracoxib synthesis Senger et al performed a retrospective

  2021-12-21

  

  Senger et al. performed a retrospective review of 17 patients with ICH on dabigatran or rivaroxaban who received 4F-PCC. Eight patients had a traumatic lumiracoxib synthesis injury (TBI) and nine patients had a spontaneous ICH. Nine patients had a devastating outcome, including severe neurologic de

• BMP signals play pivotal roles in the various processes of

  2021-12-21

  

  BMP signals play pivotal roles in the various processes of chondrogenesis [12], [13]. At early stages of chondrogenesis, BMP signaling regulates the differentiation of mesenchymal apramycin into chondrocytes via the induction of Sox9[29]. The loss of Noggin, a BMP antagonist, results in the overgrow

• A more quantitative view of kinase specificity

  2021-12-21

  

  A more quantitative view of kinase specificity suggests a continuum of phosphorylation rates for the various substrates of a particular kinase (Figure 4A). Such differences in ‘substrate quality’ can arise from variations in phosphorylation site or docking sequences and may explain why the timing or

• br Results br Discussion The twin cysteine motif is an

  2021-12-21

  

  Results Discussion The twin-cysteine motif is an evolutionary conserved motif in all primate lentiviruses except HIV-1 and some strains of SIVcpz according to sequence analysis (Bohl et al., 2013). It is assumed that only those SIVcpz which have lost the twin-cysteines successfully evolved to

• To verify DNA glycosylase AP lyase activity we have

  2021-12-21

  

  To verify DNA glycosylase/AP lyase activity we have employed a simple and efficient method to investigate based on fluorescein-labeled duplex oligonucleotides read on an automated sequencer (Allgayer et al., 2013, Lopes et al., 2007, Lopes et al., 2008). This approach using purified CpMutY proteins

• Hippo signaling is an emerging tumor suppressor pathway that

  2021-12-21

  

  Hippo signaling is an emerging tumor suppressor pathway that plays key roles in normal physiology and tumorigenesis through the regulation of cellular proliferation and survival [4]. In humans, YAP is over-expressed as a result of genomic amplification of the 11q22 locus in a wide spectrum of human

• br The concept of the axo myelin synapse Axons

  2021-12-21

  

  The concept of the axo-myelin ‘synapse’ Axons can release glutamate in a Ca+-dependent and independent manner (reviewed in [13,69]). Glutamate released from axons activates GluRs located in myelin, a feature that gave rise to the idea of the axo-myelin ‘synapse’ by analogy with classical synaptic

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2021-12-21

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by Kifunensine deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% o

• br Acknowledgements br Introduction This

  2021-12-21

  

  Acknowledgements Introduction This article, similar to those before [1,2], presents a selection of nails for those red blood cell physiologists with hammers. The various topics are not necessarily lost for, like occupants on a carousel, they reappear periodically. Sometimes, however, some arti

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