• While CART increased circulating levels of GIP

  2022-03-16

  

  While CART increased circulating levels of GIP and GLP-1 in vivo, we were unable to detect any effect of exogenous CART on GIP and GLP-1 mRNA expression or GLP-1 secretion in vitro. There is no ready explanation for this discrepancy. The CART doses used (both in vivo and in vitro) have been shown to

• Recent studies suggest that the biological importance of end

  2022-03-16

  

  Recent studies suggest that the biological importance of endogenous ghrelin becomes accentuated during exposure to more metabolically-constrained and stressful environments. Indeed, mice lacking either ghrelin or GHSR demonstrate impaired ability to adapt metabolically and/or behaviorally to caloric

• Piezo channels can be activated by many

  2022-03-16

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by AZD8931 , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the membrane by applyin

• From a cell signaling perspective given the

  2022-03-16

  

  From a cell signaling perspective, given the importance of agonist-directed signaling and biased agonism, one goal of this research update was to review the known contributions of G protein-dependent versus β-arrestin-dependent signals toward promotion of beneficial functions that FFA4 facilitates.

• Introduction High mobility group box HMGB is a nuclear prote

  2022-03-15

  

  Introduction High mobility group box 1 (HMGB1) is a nuclear protein that plays a fundamental role in the regulation of DNA-associated events such as DNA repair, transcription, and replication. HMGB1 can be translocated to the cytosol, plasma membrane, and extracellular space in response to various

• The H R antagonist cimetidine

  2022-03-15

  

  The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.

• br Results br Discussion Our current study

  2022-03-15

  

  Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros

• br Conclusion br Conflict of interest br Introduction The hu

  2022-03-15

  

  Conclusion Conflict of interest Introduction The human epithelial receptor 2 (HER2 or erbb2) is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases that act through the EGF signaling cascade [1,2]. Approximately 20% of breast cancers overexpress HER2

• One of the key epithelium derived factors required

  2022-03-15

  

  One of the key epithelium-derived factors required to maintain immune tolerance in the intestine is Indian Hedgehog (Ihh). Ihh is secreted exclusively by intestinal epithelial cells, and signals in a paracrine manner to the inhibitory receptor Patched1 (Ptch1) on fexofenadine hydrochloride receptor

• In the course of studies leading

  2022-03-15

  

  In the course of studies leading to the discovery of , modifications at the P3-P4 interface of these tripeptide-based inhibitors were examined with the goal of improving potency while maintaining a PK profile similar to . In this report, we summarize those studies which led to the identification of

• Unlike the bacterial SRP pathway for

  2022-03-15

  

  Unlike the bacterial SRP pathway for which the energetics, kinetics, and structure of almost every intermediate have been characterized, multiple questions remain for the GET pathway (Figure 3, marked with ‘?’). First, the targeting pathway demands distinct activities of Get3 before and after substr

• br Acknowledgements br Introduction Type diabetes is a progr

  2022-03-15

  

  Acknowledgements Introduction Type 2 diabetes is a progressive metabolic disorder which is characterised by chronic hyperglycaemia due to relative insulin deficiency, insulin resistance and increased hepatic glucose production [1]. The metabolism of glucose by glycolysis increases the ATP:ADP

• Abn CBD induced changes reduced microglial cell density cell

  2022-03-15

  

  Abn-CBD induced changes (reduced microglial cell density, AZD6482 australia size and a lower density of ramification) in the microglial morphology that could be compatible with a blockade of the neuroinflammation provoked by MPTPp. The absence of GPR55 transcripts in microglial cells in striatum an

• Thus synthesized thienopyrimidine derivatives were evaluated

  2022-03-15

  

  Thus synthesized thienopyrimidine derivatives were evaluated in vitro for GPR119 agonistic activity, and the results are summarized in , , . First, we fixed the 4-methylsulfonylphenyl substituent at the R position on the thienopyrimidine ring, and derivatized at the R position. As shown in , and s

• The fact that KNDy neurons activity is sensitive

  2022-03-15

  

  The fact that KNDy neurons activity is sensitive for circulating hormones related with control of Fmoc-Trp-OH australia homeostasis was demonstrated in other studies (Cejudo Roman et al., 2012; Navarro et al., 2011). It is well documented that leptin plays an important role in the regulation of the

15335 records 463/1023 page Previous Next First page 上5页 461462463464465 下5页 Last page