• Signaling through Axl can lead

  2023-10-13

  

  Signaling through Axl can lead to activation of the PI3K/Akt and Ras/MAPK pathways which promote cellular phenotypes (e.g., transformation, migration) consistent with pro-survival and pro-metastatic effects., , Inhibition of Axl activity by a variety of approaches (including pharmacologic, dominant

• Pompe disease is accompanied by the deficiency

  2023-10-13

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the Phenyl sulfate unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in t

• AP activation is known to upregulate

  2023-10-12

  

  AP-1 activation is known to upregulate downstream target genes including RSL3 D1, c-myc, Bcl-xl, MMP-9, EGFR, and specific miRNAs that are involved in progression and metastasis of tumors. Moreover, matrix metalloproteinase-2 has been shown as a downstream gene of AP-1, triggered by 15-HETE in the r

• br Secreted enzymes Only two secreted S aureus enzymes repor

  2023-10-12

  

  Secreted enzymes Only two secreted S. aureus enzymes reportedly induce apoptosis, namely, staphylococcal staphopain B (SspB) and coagulase. SspB selectively cleaved CD11b/CD18 integrin and induced an apoptosis-like cell death in neutrophils and monocytes (Smagur et al., 2009). Neutrophils or mono

• The alamarBlue test revealed that recombinant apelin

  2023-10-12

  

  The alamarBlue test revealed that recombinant apelin led to an increase in basal and IGF1- and FHS-induced ovarian cell proliferation. Apelin increased ERK1/2 and Akt protein expression, but cell proliferation returned to control levels in the presence of kinase inhibitors. This suggests that the pr

• Available data thus indicate that there

  2023-10-12

  

  Available data thus indicate that there are at least two ways that HMGA proteins can induce localized changes in the chromatin structure of inducible gene promoters, both of which involve positioned nucleosomes that must be “remodeled” before gene transcription can occur. The first mechanism is exem

• The initial demonstration of the potential of MALDI TOF

  2023-10-12

  

  The initial demonstration of the potential of MALDI-TOF MS for testing antifungal susceptibility of pathogenic fungi came from a proof-of-concept study by Marinach et al. [31] who monitored the changes of the proteome of C. albicans 265 3 receptor exposed to different concentrations of fluconazole.

• Pathological angiogenesis occurs when an imbalance

  2023-10-12

  

  Pathological angiogenesis occurs when an imbalance of endogenous proangiogenic and antiangiogenic factors occurs. Although the focus of angiogenesis-related drug development has been geared to the discovery of antiangiogenic compounds for use in pathologies where excessive angiogenesis occurs (cance

• In human epidermoid carcinoma A cells lipoxygenase

  2023-10-12

  

  In human epidermoid carcinoma A431 cells, 12-lipoxygenase was significantly increased in glutathione-depleted cells. The relative abundance of phospholipid hydroperoxide versus glutathione peroxidase seems to play an important role in controlling the lipoxygenase reaction [57]. It has been proposed

• In conclusion our study would seem to indicate that a

  2023-10-12

  

  In conclusion, our study would seem to indicate that a hydrophilic microenvironment, which is suitable to accommodate highly hydrophilic molecules with steric hindrance such as aldose hemiacetals, allows the enzyme modulation by one of its most important physiopathological substrates. It is difficul

• br Materials and methods br Results br

  2023-10-12

  

  Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi

• 9-Phenanthrol br Experimental Procedures br Acknowledgments

  2023-10-12

  

  Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmitt

• br Dihydrotestosterone in adult fish and frogs

  2023-10-12

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• Melanocyte stimulating hormone release inhibiting factor br

  2023-10-11

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the Melanocyte stimulating hormone release inhibiting factor resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine prote

• br Aromatase inhibitors The aromatase enzyme P arom

  2023-10-11

  

  Aromatase inhibitors The aromatase enzyme, P450arom, belongs to the super-family of P450 proteins which includes more than 480 members divided in 74 different families. P450arom is a unique member of family 19 [39], and is located in the endoplasmic reticulum of mammalian Caspase-3/7 Inhibitor th

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